(4-Bromophenyl)boronic acid → HCID 90406588, compound

HRID 1404166Notes

Reaction equation

HRID 1404166 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:7]=[CH:6][NH:5][C:4]=1[C:8]([O:10][CH3:11])=O.[Br:14][C:15]1[CH:20]=[CH:19][C:18](B(O)O)=[CH:17][CH:16]=1.[CH3:24][C:25]1[C:30]([CH3:31])=[C:29]([OH:32])[CH:28]=[CH:27][C:26]=1[CH2:33][CH2:34]C(OCC)=O>>[Br:14][C:15]1[CH:20]=[CH:19][C:18]([N:5]2[CH:6]=[CH:7][C:3]([C:2]([F:13])([F:12])[F:1])=[C:4]2[CH2:8][O:10][C:11]2[CH:34]=[CH:33][C:26]([CH2:27][CH2:28][CH2:29][OH:32])=[C:25]([CH3:24])[C:30]=2[CH3:31])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 79599(4-Bromophenyl)boronic acidHCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 90405535methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate

Product 1

HCID 90406588HCID 90406588, compound

Procedure

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-bromophenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedure in Example 1, Step E, and Example 2.

Sources & evidence

ORD record
ord-c8dd5bd5855748349a751e0f021ffaa0
Source dataset
uspto-grants-2014_12
Patent number
US08912227B1

Reaction notes

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