Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1404168Generated: October 25, 2026

(4-Bromophenyl)boronic acid → 3-(4-{[1-(4-Bromophenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-difluorophenyl)propanoic acid

https://huagongshe.com/reaction/1404168

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Bromophenyl)boronic acidHCID 79599—
ReactantEthyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoateHCID 90404786—
Reactantmethyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylateHCID 90405535—
Product3-(4-{[1-(4-Bromophenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-difluorophenyl)propanoic acidHCID 90406550—

Reaction Steps

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-bromophenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, and (c) then reacting the resulting product with ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate according to the procedure described in Example 1, Steps E and F.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08912227B1
Source datasetuspto-grants-2014_12
ORD IDord-ed31395f43244b7194b7843dde2f3c2d
Source noteuspto-grants-2014_12