Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1404173Generated: October 25, 2026

(4-Methoxyphenyl)boronic acid → 3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propanoic acid

https://huagongshe.com/reaction/1404173

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Methoxyphenyl)boronic acidHCID 201262—
ReactantEthyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoateHCID 90404786—
Reactantmethyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylateHCID 90405535—
Product3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propanoic acidHCID 90406129—

Reaction Steps

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-methoxyphenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, and (c) then reacting the resulting product with ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate according to the procedure described in Example 1, Steps E and F.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08912227B1
Source datasetuspto-grants-2014_12
ORD IDord-5a667105148d4af5bbc4e160156f0f17
Source noteuspto-grants-2014_12