(4-Methoxyphenyl)boronic acid → 3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propan-1-ol

Participants

Role	Name	HCID	Charge
Reactant	(4-Methoxyphenyl)boronic acid	HCID 201262	—
Reactant	Ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate	HCID 90404786	—
Reactant	methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate	HCID 90405535	—
Product	3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propan-1-ol	HCID 90407412	—

Reaction Steps

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-methoxyphenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate according to the procedure described in Example 1, Step E, and Example 2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08912227B1
Source dataset	uspto-grants-2014_12
ORD ID	ord-cd73ddd25b3d4911b2d507480f43d942
Source note	uspto-grants-2014_12