関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloropyrazine | HCID 73277 | — |
| 反応物 | 5-Amino-2-(trifluoromethyl)pyridine | HCID 2737744 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Pyrazin-2-yl-(6-trifluoromethyl-pyridin-3-yl)-amine | HCID 66615925 | — |
反応手順
To a solution of 5-amino-2-trifluoromethylpyridine (0.81 g) in 3 Ml toluene was added chloropyrazine (0.45 Ml, 1.0 equiv) via syringe. The homogeneous solution was heated to 95° C., then cooled to room temperature and concentrated in vacuo. Purification by silica gel chromatography (40% EtOAc in hexanes) afforded the title compound: 1H NMR (400 MHz, CHLOROFORM-D) δ ppm 7.5 (s, 1 H) 7.6 (s, 1 H) 8.0 (s, 1 H) 8.2 (s, 1 H) 8.4 (s, 2 H) 8.8 (s, 1 H); (M+H)+ 241.1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08912208B2 |
|---|
| 出典データセット | uspto-grants-2014_12 |
|---|
| ORD ID | ord-0c68610bfb284bd493f54d6c13c2e641 |
|---|
| 出典メモ | uspto-grants-2014_12 |
|---|
