反应详情

温度

130 °C

A solution of (5-Bromo-pyrazin-2-yl)-(6-trifluoromethyl-pyridin-3-yl)-amine (0.072 g) and {4-[4-(5-bromo-pyridin-2-yl)-phenyl]-cyclohexyl}-acetic acid methyl ester (0.087 g) in 2 Ml DME was charged with 2 M sodium carbonate (1 Ml) and Pd(PPh3)4 (0.027 g, 0.1 equiv). The biphasic mixture was sparged with nitrogen for 3 min, then stirred at 130° C. under microwave heating for 30 min. The reaction was partitioned between EtOAc and water, and the organic extracts were dried over magnesium sulphate and concentrated in vacuo. Purification by silica gel chromatography (33% EtOAc in hexanes) afforded the title compound: (M+H)+ 471.2.

1. customThe biphasic mixture was sparged with nitrogen for 3 min
2. temperatureheating for 30 min
3. customThe reaction was partitioned between EtOAc and water
4. dry with materialthe organic extracts were dried over magnesium sulphate
5. concentrationconcentrated in vacuo
6. customPurification by silica gel chromatography (33% EtOAc in hexanes)