反应详情

426 mg 4-chloro naphthyridine from example 1, 682 mg 4-isoquinoline boronic acid pinacole ester, 945 mg sodium carbonate were dissolved with 30 ml dioxan and 3 ml water, flushed with nitrogen, and 172 mg tetrakistriphenylphosphine palladium(0) were added. After 105 min reflux workup as in example 20 yielded a brownish oil, which was crystallized with ether to give 436 mg of product with correct LC-MS: M+H+ 386 and Rt˜2.22 min.

1. customflushed with nitrogen, and 172 mg tetrakistriphenylphosphine palladium(0)
2. additionwere added
3. temperatureAfter 105 min reflux workup as in example 20
4. customyielded a brownish oil, which
5. customwas crystallized with ether