反应详情

190 mg 4-chloro naphthyridine from example 3, 341 mg 4-isoquinoline boronic acid pinacole ester, 473 mg sodium carbonate were dissolved with 20 ml dioxan and 5 ml water, flushed with nitrogen, and 86 mg tetrakistriphenylphosphine palladium(0) were added. After 90 min reflux, workup as in example 20 yielded a grey-brownish oil, which was crystallized with ether to give 176 mg correct product as a brownish powder with correct LC_MS: M+H+ 349 and Rt˜1.76 min.

1. customflushed with nitrogen, and 86 mg tetrakistriphenylphosphine palladium(0)
2. additionwere added
3. temperatureAfter 90 min reflux
4. customworkup as in example 20 yielded a grey-brownish oil, which
5. customwas crystallized with ether