tert-Butyl piperazine-1-carboxylate → HCID 86722948, compound

HRID 1404341Notes

Reaction equation

HRID 1404341 reaction equation
O=[C:2]1[CH2:7][CH2:6][CH:5]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][CH2:3]1.[N:12]1([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>CO.[Pd]>[C:21]([O:20][C:18]([N:12]1[CH2:17][CH2:16][N:15]([CH:2]2[CH2:7][CH2:6][CH:5]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][CH2:3]2)[CH2:14][CH2:13]1)=[O:19])([CH3:24])([CH3:22])[CH3:23]

Participants

5

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 99204382-(4-oxocyclohexyl)acetic Acid

Product 1

HCID 86722948HCID 86722948, compoundYield 99.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To 2-(4-oxocyclohexyl)acetic acid (0.576 g, 3.7 mmol) and tert-butyl piperazine-1-carboxylate (0.700 g, 3.7 mmol) in MeOH, was added Pd on carbon (80 mg), and the resultant reaction mixture was stirred under hydrogen atmosphere overnight. The catalyst was removed via filtration and the solvent was removed under reduced pressure to afford the acid as white solid (1.2 g. 99%).

Workup

  1. customthe resultant reaction mixture
  2. customThe catalyst was removed via filtration
  3. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a9bbfb570cbb4f95bdffda50dc3aa8cf
Source dataset
uspto-grants-2014_12
Patent number
US08912169B2

Reaction notes

Loading…