HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178512226, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Propan-2-yl methanimidate--hydrogen chloride (1/1) | HCID 12801779 | — |
| Reactant | HCID 178511528 | HCID 178511528 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178512226 | HCID 178512226 | — |
Reaction Steps
To (R)-3-(2-(trans-4-aminocyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid (Example 6) in MeOH was added DIEA (2.5 eq), followed by isopropyl formimidate hydrochloride (1.2 eq). The reaction mixture was stirred at RT overnight. The mixture was then concentrated in vacuo and the crude product was purified using reverse phase HPLC to afford the title compound. ESI-MS m/z 374 (MH)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912169B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-03c80b4ac66a4457ad86b273e48f165b |
| Source note | uspto-grants-2014_12 |