Benzylamine → HCID 86722961, compound

HRID 1404357Notes

Reaction equation

HRID 1404357 reaction equation
[CH2:1]([O:8][C:9](=[O:19])[CH2:10][C:11]1([OH:18])[CH2:16][CH2:15][C:14](=O)[CH2:13][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:1]([O:8][C:9](=[O:19])[CH2:10][C:11]1([OH:18])[CH2:16][CH2:15][CH:14]([NH:27][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:13][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 86722957HCID 86722957, compound

Product 1

HCID 86722961HCID 86722961, compound

Procedure

Prepared from (1-Hydroxy-4-oxo-cyclohexyl)-acetic acid benzyl ester and benzylamine following the procedure described in Step 2 of Example 43. The crude product was purified by flash chromatography on silica gel (0-10% CH3OH:CH2Cl2). ESI-MS m/z 354 (MH)+.

Workup

  1. customThe crude product was purified by flash chromatography on silica gel (0-10% CH3OH:CH2Cl2)

Sources & evidence

ORD record
ord-0da8e236d5804dd5a7d177fbe7973c65
Source dataset
uspto-grants-2014_12
Patent number
US08912169B2

Reaction notes

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