HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178461770, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | tert-butyl N-((2S)-1-oxopropan-2-yl)carbamate | HCID 7015728 | — |
| Reactant | HCID 178511351 | HCID 178511351 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178461770 | HCID 178461770 | — |
Reaction Steps
To (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid from Example 15 (92 mg) in MeOH (2 mL) was added TEA (70 μL), acetic acid (30 μL), (S)-tert-butyl 1-oxopropan-2-ylcarbamate (86 mg) and sodium triacetoxyborohydride (212 mg). The reaction mixture was stirred overnight at RT. Solvent was removed and the product was carried on to next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912169B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-2fcae6bb83944443928dad171d20b3bc |
| Source note | uspto-grants-2014_12 |