反应详情

A mixture of 4-(4-methylpiperazin-1-ylmethyl) benzoic acid dihydrochloride (150 g), thionyl chloride (600 ml) and N,N-dimethylformamide (37.2 ml) was refluxed for 20 hours. After completion of reaction, the reaction mass was distilled out completely under vacuum to give residue which was diluted with dichloromethane (300 ml). The solid thus precipitated was filtered and washed to give 135 g of the title compound.

1. temperaturewas refluxed for 20 hours
2. customAfter completion of reaction
3. distillationthe reaction mass was distilled out completely under vacuum
4. customto give residue which
5. customThe solid thus precipitated
6. filtrationwas filtered
7. washwashed