Imatinib → Imatinib Mesylate

Participants

Reaction Steps

To a stirred suspension of imatinib (5 g) in tetrahydrofuran (20 ml) and water (10 ml), methanesulphonic acid (0.97 gl) was added to get clear solution. Reaction mixture was charcoalised and filtered. Tetrahydrofuran (75 ml) was added slowly to the reaction mixture at 25-30° C. The resulting mixture was filtered, washed with t-butylmethyl ether and dried to give 5.2 g of the title compound having purity 99.68% by HPLC.

Provenance & Evidence