Imatinib → Imatinib Mesylate

Participants

Reaction Conditions

Reaction Steps

To a mixture of imatinib (10 g) in dimethylsulfoxide (50 ml), methanesulfonic acid (2 g) was added at ambient temperature and reaction mixture was heated to 45° C. to get clear solution. Reaction mixture was filtered. 10-15% of resulting filtered solution was added to isopropanol (210 ml) at 55-60° C. and stirred for 15 minutes. Seeding of α-form (0.2 g) was added to this solution followed by the addition of remaining filtered solution and mixture was stirred for 2.0 hours at 55 to 60° C. The reaction mass was cooled to 20-25° C. and stirred for another 2 hours at 20 to 25° C. Reaction mass was filtered, washed and dried to give 9.8 g of title compound having DSC: 226° C.

Provenance & Evidence