Imatinib → Imatinib Mesylate

Participants

Reaction Conditions

Reaction Steps

Imatinib (100 g) was suspended in dimethylsulfoxide (180 ml) and methanesulfonic acid (20 g) was added to mixture at 25 to 30° C. Reaction mass was heated to 45° C. till clear solution and filtered. 10% of filtered solution was added to a mixture of isopropanol (900 ml), ethyl acetate (600 ml) and n-propanol (600 ml) and dimethylsulfoxide (300 ml) at 20° C. followed by seeding and stirred for 30 minutes. Remaining filtered solution was added to above suspension and stirred for 5.0 hours at 20-25° C. Reaction mass was filtered, washed and dried to 102 g of α-form of imatinib mesylate.

Provenance & Evidence