Triethylamine → HCID 49849017, compound

Participants

Reaction Steps

To a solution of 2-(pyridin-4-yl)morpholine in dry dichloromethane are added 1.5 eq butanoyl chloride and 2.5 eq triethylamine. After stirring for 6 hours at room temperature the solvent is removed in vacuo and the residue redisolved in ethyl acetate. The organic solution is subsequently washed with 1 M KHSO4, 5% NaHCO3 and brine. After drying over Na2SO4, ethyl acetate is removed in vacuo and the crude 1-(2-(pyridin-4-yl)morpholino)butan-1-one is purified by column chromatography.

Provenance & Evidence