2-Pyridineethanamine → HCID 49849020, compound

HRID 1404441Notes

Reaction equation

HRID 1404441 reaction equation
[CH:1]([CH:3]([CH2:9][CH3:10])[CH2:4][C:5]([O:7]C)=O)=O.[N:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][NH2:19]>C(O)(=O)C>[CH2:9]([C:3]1[CH2:1][N:19]([CH2:18][CH2:17][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][N:11]=2)[C:5](=[O:7])[CH:4]=1)[CH3:10]

Participants

4

Reactant 2

HCID 759192-PyridineethanamineHCID 11084006Methyl 3-formylpentanoate

Product 1

HCID 49849020HCID 49849020, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4-Ethyl-1-(2-(pyridin-2-yl)ethyl)-1H-pyrrol-2(5H)-one is synthesized by a cyclo-condensation between methyl 3-formylpentanoate and 2-(pyridin-2-yl)ethanamine in glacial acetic acid at 70° C. according to a procedure of R. Fisher (DE 4127111, 1992).

Sources & evidence

ORD record
ord-923485febf1a4058a336acedbf2f86f4
Source dataset
uspto-grants-2014_12
Patent number
US08912329B2

Reaction notes

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