{(R)-1-[5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethyl}-carbamic acid tert-butyl ester → 3-Amino-oxetane-3-carboxylic acid {(R)-1-[5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethyl}-amide

Participants

Role	Name	HCID	Charge
Reactant	{(R)-1-[5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethyl}-carbamic acid tert-butyl ester	HCID 67979243	—
Reactant	4'-{(R)-1-[(3-Amino-oxetane-3-carbonyl)-amino]-ethyl}-3-chloro-3'-fluoro-biphenyl-2-carboxylic acid methyl ester	HCID 67979497	—
Product	3-Amino-oxetane-3-carboxylic acid {(R)-1-[5'-chloro-3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethyl}-amide	HCID 67979305	—

Reaction Steps

The title compound was prepared in analogy to intermediate 4 using a modified procedure in step A for the synthesis of {(R)-1-[5′-chloro-3,3′-difluoro-2′-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethyl}-carbamic acid tert-butyl ester:

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08912221B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-8ff3aa99249c4236a85c88f28fc56046
Source note	uspto-grants-2014_12