Hydrochloric Acid → Benzenemethanamine, 4-bromo-2-fluoro-.alpha.-methyl-, hydrochloride (1:1), (.alpha.R)-

Participants

Reaction Steps

To a solution of (S)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-bromo-2-fluoro-phenyl)-ethyl]-amide (4.02 g, 12.5 mmol) in methanol (25 ml) was added a 4M HCl solution in dioxane (6.24 ml, 25.0 mmol) and the mixture was stirred for 4 h. The reaction mixture was then concentrated and diethyl ether was added. The resulting suspension was stirred for 2 h and then filtered to deliver the title compound as white solid (3.11 g, 98%).

Provenance & Evidence