HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrimidine-5-carboxylic acid → 3-Chloro-3'-fluoro-4'-[(R)-1-({3-[(pyrimidine-5-carbonyl)-amino]-oxetane-3-carbonyl}-amino)-ethyl]-biphenyl-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrimidine-5-carboxylic acid | HCID 78346 | — |
| Reactant | 4'-{(R)-1-[(3-Amino-oxetane-3-carbonyl)-amino]-ethyl}-3-chloro-3'-fluoro-biphenyl-2-carboxylic acid methyl ester | HCID 67979497 | — |
| Product | 3-Chloro-3'-fluoro-4'-[(R)-1-({3-[(pyrimidine-5-carbonyl)-amino]-oxetane-3-carbonyl}-amino)-ethyl]-biphenyl-2-carboxylic acid methyl ester | HCID 57382794 | — |
Reaction Steps
The title compound was prepared in analogy to example 1 using intermediate 4 instead of intermediate 1 and pyrimidine-5-carboxylic acid instead of 3-fluoro-5-(trifluoromethyl)benzoic acid and was obtained as white solid. MS: 513.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912221B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-ea5f3cdc1d584315bb05dabbe818923f |
| Source note | uspto-grants-2014_12 |