HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methylisoxazole-5-carboxylic acid → 3-Chloro-3'-fluoro-4'-[(R)-1-({3-[(3-methyl-isoxazole-5-carbonyl)-amino]-oxetane-3-carbonyl}-amino)-ethyl]-biphenyl-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methylisoxazole-5-carboxylic acid | HCID 853085 | — |
| Reactant | 4'-{(R)-1-[(3-Amino-oxetane-3-carbonyl)-amino]-ethyl}-3-chloro-3'-fluoro-biphenyl-2-carboxylic acid methyl ester | HCID 67979497 | — |
| Product | 3-Chloro-3'-fluoro-4'-[(R)-1-({3-[(3-methyl-isoxazole-5-carbonyl)-amino]-oxetane-3-carbonyl}-amino)-ethyl]-biphenyl-2-carboxylic acid methyl ester | HCID 57382837 | — |
Reaction Steps
The title compound was prepared in analogy to example 1 using intermediate 4 instead of intermediate 1 and 3-methylisoxazole-5-carboxylic acid instead of 3-fluoro-5-(trifluoromethyl)benzoic acid and was obtained as white solid. MS: 516.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912221B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-a4353adbf4434428b1b8cadffc294483 |
| Source note | uspto-grants-2014_12 |