(4-(N-(2-Hydroxyethyl)sulfamoyl)phenyl)boronic acid → HCID 58532382, compound

HRID 1404587Notes

Reaction equation

HRID 1404587 reaction equation
Br[C:2]1[CH:3]=[C:4]2[N:10]([O:11][CH:12]([C:14]3[C:19]([Cl:20])=[CH:18][CH:17]=[C:16]([F:21])[C:15]=3[Cl:22])[CH3:13])[CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[OH:23][CH2:24][CH2:25][NH:26][S:27]([C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)(=[O:29])=[O:28]>>[Cl:22][C:15]1[C:16]([F:21])=[CH:17][CH:18]=[C:19]([Cl:20])[C:14]=1[CH:12]([O:11][N:10]1[C:4]2[C:5](=[N:6][CH:7]=[C:2]([C:33]3[CH:34]=[CH:35][C:30]([S:27]([NH:26][CH2:25][CH2:24][OH:23])(=[O:29])=[O:28])=[CH:31][CH:32]=3)[CH:3]=2)[CH:8]=[CH:9]1)[CH3:13]

Participants

3

Reactant 2

HCID 44119332(4-(N-(2-Hydroxyethyl)sulfamoyl)phenyl)boronic acidHCID 674584186-bromo-1-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[3,2-b]pyridine

Product 1

HCID 58532382HCID 58532382, compound

Procedure

The entitled compound was prepared from 6-bromo-1-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[3,2-b]pyridine and {4-[(2-hydroxyethyl)sulfamoyl]phenyl}boronic acid according to the procedure described in example 4.

Sources & evidence

ORD record
ord-04c35f30a86d49d78235d4ba2cb969d8
Source dataset
uspto-grants-2014_12
Patent number
US08912330B2

Reaction notes

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