5-Fluoro-2-(trifluoromethyl)benzyl bromide → 1-{[5-fluoro-2-(trifluoromethyl)benzyl]oxy}-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[3,2-b]pyridine

Participants

Role	Name	HCID	Charge
Reactant	5-Fluoro-2-(trifluoromethyl)benzyl bromide	HCID 2737578	—
Reactant	tert-butyl 4-[4-(1-hydroxy-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate	HCID 67458749	—
Product	1-{[5-fluoro-2-(trifluoromethyl)benzyl]oxy}-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[3,2-b]pyridine	HCID 86659799	—

Reaction Steps

The entitled compound is prepared from tert-butyl 4-[4-(1-hydroxy-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate and 2-(bromomethyl)-4-fluoro-1-(trifluoromethyl)benzene as described in the last 2 steps of Example 18.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08912330B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-a9fa9d3da6554eb8923a95d192b83af3
Source note	uspto-grants-2014_12