1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1-{[4-(trifluoromethoxy)benzyl]oxy}-1H-pyrrolo[3,2-b]pyridine

Participants

Role	Name	HCID	Charge
Reactant	1-(Bromomethyl)-4-(trifluoromethoxy)benzene	HCID 142785	—
Reactant	tert-butyl 4-[4-(1-hydroxy-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate	HCID 67458749	—
Product	6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1-{[4-(trifluoromethoxy)benzyl]oxy}-1H-pyrrolo[3,2-b]pyridine	HCID 58532359	—

Reaction Steps

The entitled compound is prepared from tert-butyl 4-[4-(1-hydroxy-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate and 1-(bromomethyl)-4-(trifluoromethoxy)benzene as described in the last 2 steps of Example 18.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08912330B2
Source dataset	uspto-grants-2014_12
ORD ID	ord-7489345e93094aa387410821bee9abfc
Source note	uspto-grants-2014_12