HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopyrimidine → 6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1-(pyrimidin-2-yloxy)-1H-pyrrolo[3,2-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopyrimidine | HCID 78345 | — |
| Reactant | tert-butyl 4-[4-(1-hydroxy-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate | HCID 67458749 | — |
| Product | 6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1-(pyrimidin-2-yloxy)-1H-pyrrolo[3,2-b]pyridine | HCID 58532443 | — |
Reaction Steps
The entitled compound is prepared from tert-butyl 4-[4-(1-hydroxy-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate and 2-bromo-pyrimidine as described in the last 2 steps of Example 18.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912330B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-6d5d63ec183c40bf9c679d8eac4d5936 |
| Source note | uspto-grants-2014_12 |