Fluorobenzene → HCID 86659800, compound

Participants

Reaction Steps

6-bromo-1H-pyrrolo[3,2-b]pyridin-1-ol (prepared as in Example 1: 200 mg, 1.0 mmol, 1.0 eq), fluorobenzene (485 mg, 5.0 mmol, 5.0 eq), and K2CO3 (690 mg, 5.0 mmol, 5.0 eq) in 2 ml of DMF were microwaved (160° C.) for 30 min. The reaction mixture was allowed to cool to room temperature, the solvent was evaporated, and the mixture was chromatographed (MeOH/DCM 1:20) to give a light yellow solid, 110 mg, in 50% yield.

Provenance & Evidence