HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,6-Dichloro-3-fluorophenyl)ethanone → N-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[3,2-b]pyridin-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,6-Dichloro-3-fluorophenyl)ethanone | HCID 2733982 | — |
| Reactant | tert-butyl 4-[4-(1-amino-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate | HCID 58532283 | — |
| Product | N-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-6-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]-1H-pyrrolo[3,2-b]pyridin-1-amine | HCID 58532258 | — |
Reaction Steps
The entitled compound was prepared as described in example 27 by condensing tert-butyl 4-[4-(1-amino-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate (prepared in example 18:100 mg, 0.26 mmol) with 1-(2,6-dichloro-3-fluorophenyl)ethanone (excess). The reduction of imine and BOC-deprotection were also carried out as described in Example 27.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912330B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-d5aa360da4134ef0a36ac7ffd622bc35 |
| Source note | uspto-grants-2014_12 |