Hydrochloric Acid → HCID 178478039, compound

Participants

Reaction Steps

To stirred solution of tert-butyl 5-(2-chlorobenzylthio)-2-(pyridin-2-yl)-1H-benzo[d]imidazole-1-carboxylate (or the isomer, tert-butyl 6-(2-chlorobenzylthio)-2-(pyridin-2-yl)-1H-benzo[d]imidazole-1-carboxylate) (18 mg, 0.04 mmol) in methanol (2 mL) was added 4M HCl in dioxane (1 mL, 4 mmol) and the reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and the residue was purified by reverse phase preparative HPLC to give 5-(2-chlorobenzylthio)-2-(pyridin-2-yl)-1H-benzo[d]imidazole (2TFA) (8.8 mg, 38%).

Provenance & Evidence