Benzoyl chloride → Benzophenone

Participants

Reaction Conditions

Reaction Steps

51.3 g (300 mmol) of m-bromomethylthiobenzene was added dropwise to a dichloromethane (350 ml) solution containing 47.9 g (359.6 mmol) of aluminum chloride and 42.4 g (300 mmol) of benzoyl chloride which was cooled to 0° C. After addition, the resulting mixture was stirred for 2 hours. After a reaction, the reaction solution was washed with water, the solvent was removed, and the obtained product was purified by column chromatography to obtain a benzophenone derivative represented by the following formula (35) as 58.1 g (189 mmol, yield of 63%) of a yellow solid.

Provenance & Evidence