2-Bromoanisole → Benzophenone

Participants

Reaction Conditions

Reaction Steps

60.6 g (324.2 mmol) of 2-bromoanisole was added dropwise to a dichloromethane (350 ml) solution containing 51.8 g (388.6 mmol) of aluminum chloride and 55.31 g (324.3 mmol) of 3-methoxybenzoyl chloride which was cooled to 0° C. After addition, the resulting mixture was stirred for 2 hours. After a reaction, the reaction solution was washed with water, the solvent was removed, and the obtained product was purified by column chromatography to obtain a benzophenone derivative represented by the following formula (47) as 67.7 g (210.7 mmol, yield of 65%) of a yellow solid.

Provenance & Evidence