2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one → HCID 59467896, compound

HRID 1404911Notes

Reaction equation

HRID 1404911 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4].[CH3:15][O:16][C:17]1[CH:18]=[CH:19][C:20]2[S:24][C:23]([SH:25])=[N:22][C:21]=2[CH:26]=1>>[N:5]1([C:3](=[O:4])[CH2:2][S:25][C:23]2[S:24][C:20]3[CH:19]=[CH:18][C:17]([O:16][CH3:15])=[CH:26][C:21]=3[N:22]=2)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 2401372-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-oneHCID 178488276HCID 178488276, compound

Product 1

HCID 59467896HCID 59467896, compoundYield 83%

Procedure

The title compound was synthesized according to General Procedure A using compound 4 as the electrophile and 5-methoxybenzo[d]thiazole-2-thiol as the nucleophile to yield 18 as a pale yellow solid (83%): MS m/z: 371 (M+H)+. Anal. Calcd. For, C19H18N2O2S2: C, 61.60; H, 4.90; N, 7.56; S, 17.31. Found: C, 61.40; H, 4.90; N, 7.48; S, 17.26.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-7b60e63a8f3b40c49c79bdfb6ca39e25
Source dataset
uspto-grants-2014_12
Patent number
US08916550B2

Reaction notes

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