2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one → HCID 59467909, compound

HRID 1404915Notes

Reaction equation

HRID 1404915 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8][CH2:7][CH2:6]1)=[O:4].[Cl:15][C:16]1[C:21]2[N:22]=[C:23]([SH:25])[S:24][C:20]=2[CH:19]=[CH:18][CH:17]=1>>[Cl:15][C:16]1[C:21]2[N:22]=[C:23]([S:25][CH2:2][C:3]([N:5]3[C:14]4[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=4)[CH2:8][CH2:7][CH2:6]3)=[O:4])[S:24][C:20]=2[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 2401372-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-oneHCID 178527804HCID 178527804, compound

Product 1

HCID 59467909HCID 59467909, compoundYield 72%

Procedure

The title compound was synthesized according to General Procedure A using compound 4 as the electrophile and 4-chlorobenzo[d]thiazole-2-thiol as the nucleophile to yield 22 as a white solid (72%): MS m/z: 375 (M+H)+. Anal. Calcd. For, C18H15ClN2OS2: C, 57.67; H, 4.03; N, 7.47; S, 17.11; Cl, 9.46. Found: C, 57.79; H, 4.08; N, 7.48; S, 17.33; Cl, 9.41.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-e82da153be6746e99679d76a7807ae65
Source dataset
uspto-grants-2014_12
Patent number
US08916550B2

Reaction notes

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