HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one → 1-(3,4-Dihydro-2H-quinolin-1-yl)-2-(5-trifluoromethyl-benzothiazol-2-ylsulfanyl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one | HCID 240137 | — |
| Reactant | 5-(trifluoromethyl)-1,3-benzothiazole-2-thiol | HCID 178419087 | — |
| Product | 1-(3,4-Dihydro-2H-quinolin-1-yl)-2-(5-trifluoromethyl-benzothiazol-2-ylsulfanyl)-ethanone | HCID 59467897 | 80% |
Reaction Steps
The title compound was synthesized according to General Procedure A using compound 4 as the electrophile and 5-(trifluoromethyl)benzo[d]thiazole-2-thiol as the nucleophile to yield 23 as a white solid (80%): MS m/z: 409 (M+H)+. Anal. Calcd. For, C19H15F3N2OS2: C, 55.87; H, 3.70; N, 6.86; S, 15.70; F, 13.95. Found: C, 55.79; H, 3.71; N, 6.92; S, 15.67; F, 14.07.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916550B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-c9448649a6804c90b3ae0f80a84ee16b |
| Source note | uspto-grants-2014_12 |