HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one → 2-(7-Chloro-benzothiazol-2-ylsulfanyl)-1-(3,4-dihydro-2H-quinolin-1-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one | HCID 240137 | — |
| Reactant | 7-Chloro-2-mercaptobenzothiazole | HCID 178527784 | — |
| Product | 2-(7-Chloro-benzothiazol-2-ylsulfanyl)-1-(3,4-dihydro-2H-quinolin-1-yl)-ethanone | HCID 59467908 | 46% |
Reaction Steps
The title compound was synthesized according to General Procedure A using compound 4 as the electrophile and 7-chlorobenzo[d]thiazole-2-thiol as the nucleophile to yield 26 as a white solid (46%): MS m/z: 375 (M+H)+. Anal. Calcd. For, C18H15ClN2OS2: C, 57.67; H, 4.03; N, 7.47; S, 17.11; Cl, 9.46. Found: C, 57.50; H, 3.99; N, 7.47; S, 17.36; Cl, 9.52.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916550B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-431e36bbe2794e1ca8eebe269b85069d |
| Source note | uspto-grants-2014_12 |