HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one → 1-(3,4-dihydroquinolin-1(2H)-yl)-2-(4,5-dimethylthiazol-2-ylthio)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one | HCID 240137 | — |
| Reactant | 4,5-dimethyl-1,3-thiazole-2-thiol | HCID 178433562 | — |
| Product | 1-(3,4-dihydroquinolin-1(2H)-yl)-2-(4,5-dimethylthiazol-2-ylthio)ethanone | HCID 59467913 | 74% |
Reaction Steps
The title compound was synthesized according to General Procedure A using compound 4 as the electrophile and 4,5-dimethylthiazole-2-thiol as the nucleophile to yield 33 as a cream solid (690 mg, 74%). MS (APCI): m/z 319 [M+H]+. Anal. Calcd. for C16H18N2OS2: C, 60.34; H, 5.70; N, 8.80. Found: C, 60.51; H, 5.71; N, 8.72.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916550B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-542ae99b91144d2eb7c46d819f54b2bd |
| Source note | uspto-grants-2014_12 |