HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one → 2-(4-tert-butylthiazol-2-ylthio)-1-(3,4-dihydroquinolin-1(2H)-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-1-(1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one | HCID 240137 | — |
| Reactant | HCID 178441426 | HCID 178441426 | — |
| Product | 2-(4-tert-butylthiazol-2-ylthio)-1-(3,4-dihydroquinolin-1(2H)-yl)ethanone | HCID 5003610 | 37% |
Reaction Steps
The title compound was synthesized according to General Procedure A using compound 4 as the electrophile and 4-tert-butylthiazole-2-thiol as the nucleophile to yield 34 (37%): MS: m/z+ 347.2 [M+H]+. Anal. Calcd (found) for C18H22N2OS2: C, 62.39 (62.60); H, 6.40 (6.43); N, 8.08 (8.06); S, 18.50 (18.39).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916550B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-f9305aa549684cb7885f984118dadb08 |
| Source note | uspto-grants-2014_12 |