2-(2-Benzothiazolylthio)acetic acid → 1-(2-(Benzo[d]thiazol-2-ylthio)acetyl)-1,2,3,4-tetrahydro-benzo[b]azepin-5-one

HRID 1404925Notes

Reaction equation

HRID 1404925 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][C:12]([OH:14])=O.[NH:15]1[CH2:21][CH2:20][CH2:19][C:18](=[O:22])[C:17]2[CH:23]=[CH:24][CH:25]=[CH:26][C:16]1=2>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][C:12]([N:15]1[CH2:21][CH2:20][CH2:19][C:18](=[O:22])[C:17]2[CH:23]=[CH:24][CH:25]=[CH:26][C:16]1=2)=[O:14]

Participants

3

Reactant 2

HCID 805252-(2-Benzothiazolylthio)acetic acidHCID 2947881,2,3,4-Tetrahydro-benzo(b)azepin-5-one

Product 1

HCID 594678811-(2-(Benzo[d]thiazol-2-ylthio)acetyl)-1,2,3,4-tetrahydro-benzo[b]azepin-5-oneYield 29%

Procedure

The title compound was synthesized according to General Procedure B using 2-(benzo[d]thiazol-2-ylthio)acetic acid and 1,2,3,4-tetrahydrobenzo[b]azepin-5-one (5) to yield 37 (160 mg, 29%): MS (APCI): m/z 369 [M+H]+. Anal. Calcd. for C19H16N2O2S2: C, 61.93; H, 4.38; N, 7.60. Found: C, 61.72; H, 4.31; N, 7.40.

Workup

  1. customThe title compound was synthesized

Sources & evidence

ORD record
ord-e2082c18c13c46398ca2f00ba6e396b7
Source dataset
uspto-grants-2014_12
Patent number
US08916550B2

Reaction notes

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