Potassium Carbonate → HCID 67959076, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methyl 4-bromo-3-hydroxythiophene-2-carboxylate (53.0 g), potassium carbonate (46.2 g), 2-bromoacetamide (37.0 g) and DMF (500 ml) was stirred at 60° C. for 2 hr, and the solvent was evaporated under reduced pressure. Water (300 ml) was added to the residue, and the solid was collected by filtration. To the obtained solid were added potassium carbonate (61.6 g), water (20 ml) and MeOH (500 ml, and the mixture was stirred at 85° C. for 1 hr. After cooling to room temperature, the solid were collected by filtration. The obtained solid was dissolved in water (300 mL), and the mixture was adjusted with 6 N hydrochloric acid to pH 3. The obtained solid was collected by filtration, and washed with water to give the title compound (50.5 g, 80.8%) as a solid.

Provenance & Evidence