1-Hydroxybenzotriazole → HCID 67959191, compound

Participants

Reaction Steps

To a solution of 3-(2-amino-2-oxoethoxy)-4-bromothiophene-2-carboxylic acid (50.5 g), 1-hydroxybenzotriazole 1 hydrate (24.4 g) and DMF (500 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (34.5 g), and the mixture was stirred at room temperature for 4 hr. To the reaction mixture was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (34.5 g), and the mixture was stirred at room temperature for 12 hr. To the reaction mixture was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (34.5 g), and the mixture was stirred at room temperature for 7 hr. The solvent was evaporated under reduced pressure, and water (500 mL) was added to the residue to give the title compound (38.8 g, 82.2%) as a solid.

Provenance & Evidence