Hydrogen chloride-ethyl acetate → HCID 50925146, compound

Participants

Reaction Steps

tert-Butyl 8-(3-fluorophenyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (209 mg) was dissolved in ethyl acetate (2 ml), and 4 N hydrogen chloride-ethyl acetate solution (2 ml) was added. The mixture was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of MeOH and Et2O to give 8-(3-fluorophenyl)-2,3,4,5-tetrahydrothieno[2,3-f][1,4]oxazepine 1 hydrochloride (142 mg, 83.0%) as a solid.

Provenance & Evidence