Trifluoroacetic acid → HCID 67959293, compound

Participants

Reaction Steps

A solution of methyl 4-bromo-3-(2-tert-butoxy-1-methyl-2-oxoethoxy)thiophene-2-carboxylate (890 mg) and trifluoroacetic acid (5 ml) was stirred at room temperature for 20 min. The reaction mixture was concentrated under reduced pressure, and the obtained residue was diluted with ethyl acetate, washed with water and saturated brine, and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of Et2O and hexane to give the title compound (715 mg, 95%) as colorless crystals.

Provenance & Evidence