Dimethylformamide → HCID 67958927, compound

Participants

Reaction Steps

A solution of 3-(2-amino-1-methyl-2-oxoethoxy)-4-bromothiophene-2-carboxylic acid (400 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (521 mg), 1-hydroxybenzotriazole 1 hydrate (417 mg) and DMF (4 mL) was stirred at room temperature for 1.5 hr. Water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine, and dried over magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of Et2O and hexane to give the title compound (290 mg, 77%) as colorless crystals.

Provenance & Evidence