Dichloromethane → tert-Butyl 2-(5-Bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
Reaction equation
[Br:19][c:20]1[c:21](=[O:28])[n:22]([CH3:27])[cH:23][c:24]([Br:26])[cH:25]1.[C:29](=[O:30])([O-:31])[O-:32].[Cl:97][CH2:98][Cl:99].[Cs+:33].[Cs+:34].[NH2:1][c:2]1[n:3][c:4]2[c:9]([cH:10][cH:11]1)[CH2:8][N:7]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:6][CH2:5]2.[O:35]1[CH2:36][CH2:37][O:38][CH2:39][CH2:40]1.[O:43]=[C:44]([CH:45]=[CH:46][c:47]1[cH:48][cH:49][cH:50][cH:51][cH:52]1)[CH:53]=[CH:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1.[O:61]=[C:62]([CH:63]=[CH:64][c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1)[CH:71]=[CH:72][c:73]1[cH:74][cH:75][cH:76][cH:77][cH:78]1.[O:79]=[C:80]([CH:81]=[CH:82][c:83]1[cH:84][cH:85][cH:86][cH:87][cH:88]1)[CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1.[Pd:41].[Pd:42]>>[NH:1]([c:2]1[n:3][c:4]2[c:9]([cH:10][cH:11]1)[CH2:8][N:7]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:6][CH2:5]2)[c:20]1[c:21](=[O:28])[n:22]([CH3:27])[cH:23][c:24]([Br:26])[cH:25]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-05558ed4564342bab00d077ff5f92658
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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