tert-butyl 2-methyl-8-(1-methylethenyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate → HCID 67959183, compound

Participants

Reaction Steps

To a solution of tert-butyl 2-methyl-8-(1-methylethenyl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (269 mg) in THF-MeOH (2:1, 15 ml) was added 10% palladium on carbon (30 mg), and the mixture was stirred for 2 hr under a hydrogen atmosphere. The reaction solution was filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (solvent gradient; 0→10% ethyl acetate/hexane) to give the title compound (243 mg, 90%) as a colorless oil.

Provenance & Evidence