Sodium Thiosulfate → HCID 67959407, compound

Participants

Reaction Steps

A solution of tert-butyl 8-cyclopropyl-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (375 mg) obtained in Example 3, step 1, N-bromosuccinimide (237 mg) and acetonitrile (3 ml) was stirred at room temperature for 2 hr, 10% aqueous sodium thiosulfate solution was added, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (solvent gradient; 2→10% ethyl acetate/hexane) to give the title compound (359 mg, 75%) as an oil.

Provenance & Evidence