1,2-Dimethoxyethane → HCID 67959218, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydrothieno[2,3-f][1,4]oxazepine-4(5H)-carboxylate (300 mg), 2-bromo-3,3,3-trifluoropropene (0.2 ml), tetrakis(triphenylphosphine)palladium(0) (25.5 mg), saturated aqueous sodium carbonate solution (7 ml) and dimethoxyethane (10 ml) was stirred at 85° C. for 12 hr under an argon atmosphere. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with water, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=9:1) to give the title compound (140 mg, 50.9%) as an oil.

Provenance & Evidence