HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-chloro-6-methylpyrimidine → 4-Methyl-6-(3-methylphenyl)-2-pyrimidinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-chloro-6-methylpyrimidine | HCID 21810 | — |
| Reactant | 3-Tolylboronic acid | HCID 2733950 | — |
| Product | 4-Methyl-6-(3-methylphenyl)-2-pyrimidinamine | HCID 58513555 | — |
Reaction Steps
The title compound is synthesized according to general procedure GP4 starting from 2.0 g (14 mmol) 2-amino-4-chloro-6-methylpyrimidine and 2.5 g (18 mmol) 3-methyl-phenyl boronic acid. Yield after extraction and re-crystallization from diethylether: 4.1 g (>100%, approximately 70% pure).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08916548B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-8c673d2a4f184d7385067374ab706f2d |
| Source note | uspto-grants-2014_12 |