2-Amino-4-chloro-6-methylpyrimidine → HCID 58513173, compound

HRID 1405013Notes

Reaction equation

HRID 1405013 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][C:11]1[CH:12]=[C:13](B(O)O)[CH:14]=[C:15]([CH3:17])[CH:16]=1>>[CH3:9][C:4]1[CH:5]=[C:6]([C:13]2[CH:14]=[C:15]([CH3:17])[CH:16]=[C:11]([CH3:10])[CH:12]=2)[N:7]=[C:2]([NH2:1])[N:3]=1

Participants

3

Reactant 2

HCID 218102-Amino-4-chloro-6-methylpyrimidineHCID 27343493,5-Dimethylphenylboronic acid

Product 1

HCID 58513173HCID 58513173, compound

Procedure

The title compound is synthesized according to general procedure GP4 starting from 2.0 g (14 mmol) 2-amino-4-chloro-6-methylpyrimidine and 2.7 g (18 mmol) 3,5-dimethyl-phenyl boronic acid. Yield after extraction and crystallization from diethylether: 3.2 g (75%, approximately 70% pure).

Workup

  1. customYield
  2. extractionafter extraction and crystallization from diethylether

Sources & evidence

ORD record
ord-91c046a5b3d74020a25aa720fbc49e52
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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