N-Iodosuccinimide → HCID 58513310, compound

HRID 1405015Notes

Reaction equation

HRID 1405015 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:5]=[C:4]([NH2:18])[N:3]=1.C1C(=O)N([I:26])C(=O)C1>C(Cl)Cl.CO>[I:26][C:7]1[C:2]([CH3:1])=[N:3][C:4]([NH2:18])=[N:5][C:6]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=1

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 21846321HCID 21846321, compound

Product 1

HCID 58513310HCID 58513310, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is synthesized according to general procedure GP1 starting from 5.0 g (14 mmol) 4-methyl-6-(3-trifluoromethyl-phenyl)-pyrimidin-2-ylamine and 3.3 g (15 mmol) NIS. Yield after chromatography on silica gel with DCM/MeOH: 3.8 g (73%).

Sources & evidence

ORD record
ord-9c9d3bad2b5a498f8e2736ecbd646d8d
Source dataset
uspto-grants-2014_12
Patent number
US08916548B2

Reaction notes

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